from the north (Basel, Zurich):

• motorway A2, direction to south
• Exit "Lugano-Nord"
• then you orient yourselves at the direction references according to the map

from the south (Rome, Milan)

• motorway direction Chiasso, CH
• after the border on the motorway A2, direction to north
• Exit "Lugano-Süd"
• then you orient yourselves at the direction references according to the map